Determining Mutation Rates in Bacterial Populations
نویسندگان
چکیده
منابع مشابه
Fitness-dependent mutation rates in finite populations.
Mutation rate may be condition dependent, whereby individuals in poor condition, perhaps from high mutation load, have higher mutation rates than individuals in good condition. Agrawal (J. Evol. Biol.15, 2002, 1004) explored the basic properties of fitness-dependent mutation rate (FDMR) in infinite populations and reported some heuristic results for finite populations. The key parameter governi...
متن کاملA model for mutation in bacterial populations
We describe the evolution of E.coli populations through a Bak-Sneppen type model which incorporates random mutations. We show that, for a value of the mutation level which coincides with the one estimated from experiments, this model reproduces the measures of mean fitness relative to that of a common ancestor, performed for over 10,000 bacterial generations. The last decade has seen a renewed ...
متن کاملModel for mutation in bacterial populations.
We describe the evolution of E. coli populations through a Bak-Sneppen-type model which incorporates random mutations. We show that, for a value of the mutation level which coincides with the one estimated from experiments, this model reproduces the measures of mean fitness relative to that of a common ancestor, performed for over 10,000 bacterial generations.
متن کاملEvolution of Mutation Rates in Rapidly Adapting Asexual Populations.
Mutator and antimutator alleles often arise and spread in both natural microbial populations and laboratory evolution experiments. The evolutionary dynamics of these mutation rate modifiers are determined by indirect selection on linked beneficial and deleterious mutations. These indirect selection pressures have been the focus of much earlier theoretical and empirical work, but we still have a...
متن کاملMutation Rates of Bacteria in Steady State Populations
The breeder and the chemostat have been used to measure mutation rates for two mutations under a variety of steady state growth conditions. These rates have been found to be higher in complex medium than in minimal (F) medium. The effects of changes in nutritional conditions on these high rates have been described. In addition, the mutation rates at short generation times, in complex medium, ha...
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ژورنال
عنوان ژورنال: Methods
سال: 2000
ISSN: 1046-2023
DOI: 10.1006/meth.1999.0901